Paracetamol poisoning below toxic level causing liver damage in a fasting adult
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چکیده
منابع مشابه
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
In many countries, paracetamol ranks at the top of all known poisoning agents implicated in accidental or intentional poisoning [1]. In general, liver injury caused by drugs is known to be either type A “dose dependent” (intrinsic toxicity) or type B idiosyncratic. Perhaps with the exception of single high dose of drug induced liver injury, most drug induced liver injury (DILI) cases evaluated ...
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A 15 year old girl was admitted 55 hours after taking an unspecified quantity of paracetamol. She was fully conscious and oriented. Her pulse rate was 88 beats/ min regular and blood pressure 110/70 mm Hg. The liver edge was palpable and tender. Plasma paracetamol concentration was 41 mg/I, serum sodium concentration 138 mmol/l, serum potassium concentration 4-2 mmol/l, plasma urea concentratio...
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Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol. One patient with liver damage survived renal failure due to acute tubular n...
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West Midlands Centre for Adverse Drug Reactions, City Hospital, Birmingham, UK School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK National Poisons Information Service, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK University/BHF Centre for Cardiovascular Science, Edinburgh University, Queen’s Medical Research Ins...
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Background Aim. In case of high-dose acetaminophen intake, the active metabolite can not bind to the glutathione, thereby inducing cellular necrosis through binding to the cytosol proteins. This trial was performed to histologically and biochemically investigate whether leptin was protective against liver damage induced by paracetamol at toxic doses. Material and Method. In our trial, 30 female...
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ژورنال
عنوان ژورنال: Ceylon Medical Journal
سال: 2009
ISSN: 2386-1274,0009-0875
DOI: 10.4038/cmj.v54i1.467